Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action PMC

CBD is a well-tolerated and safe natural compound exerting analgesic effects in various animal models of pain, as well as clinical studies. The referenced studies indicate a positive influence of CBD in treatment for various diseases in both pre-clinical and clinical trials. In the majority of animal studies, CBD has been demonstrated to exert analgesic effects, diminishing hyperalgesia and mechanical/thermal allodynia through various routes of administration. When co-administered with Δ9-THC, cbd oil for pain may reduce the effective dose and diminish negative side effects of Δ9-THC .

Effects of cannabidiol on the function of α7-nicotinic acetylcholine receptors. Yang K.H., Galadari S., Isaev D., Petroianu G., Shippenberg T.S., Oz M. The nonpsychoactive cannabinoid cannabidiol inhibits 5- hydroxytryptamine3A receptor-mediated currents in xenopus laevis oocytes. Nabissi M., Morelli M.B., Santoni M., Santoni G. Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents. Russo E.B., Burnett A., Hall B., Parker K.K. Agonistic properties of cannabidiol at 5-HT1a receptors. Toczek M., Malinowska B. Enhanced endocannabinoid tone as a potential target of pharmacotherapy.

CBD works together with the ECS to function as an anti-oxidant, to decrease inflammation, and to act as a pain reliever . Chronic pain is longer in duration and comes, lasts, and goes over multiple months or years. It can result from a plethora of health conditions such as arthritis, chronic migraine, fibromyalgia, or cancer. Blake D.R., Robson P., Ho M., Jubb R.W., McCabe C.S. Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine in the treatment of pain caused by rheumatoid arthritis.

Acute CBD treatment may not be sufficient to combat the cause of the pain and provide an effect lasting up to several hours . Although there are many cannabinoids present in cannabis, Δ9tetrahydrocannabinol (Δ9-THC) and cannabidiol are the two components found in the highest concentrations. CBD itself does not produce typical behavioral cannabimimetic effects and was thought not to be responsible for psychotropic effects of cannabis.

Cannabinoids – both endogenous and exogenous – bind to endocannabinoid receptors that are attached to cells, which stimulates different cell responses that influence pain signaling pathways. This can change the way our body perceives pain, as well as create pain-relieving and anti-inflammatory effects. Each dose of the oil contains 66mg of CBD and you can verify the potency for yourself by viewing the independent lab test results online, or by scanning the QR code on the packaging. The certificate of analysis also verifies the presence of numerous minor cannabinoids and over a dozen terpenes, which may help boost the pain-relieving and anti-inflammatory benefits of CBD.

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